A three-year-old girl has been killed and three other people have been injured in a head-on collision in Queensland's southeast.

Police say two cars travelling in opposite directions collided on the Gatton Esk Road at Buaraba, south of Esk, at around 7.50pm on Saturday.

A three-year-old girl from Esk died at the scene.

A 25-year old woman was airlifted to Royal Brisbane and Women's Hospital with serious injuries and a 24-year-old man was taken to the Princess Alexandra Hospital, also suffering serious injuries.

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A four-year-old boy was taken to Gatton Hospital with non-life threatening injuries.

The driver of the other vehicle, a 24-year-old man was also taken to Gatton Hospital with non-life threatening injuries.

Forensic Crash Unit officers are examining the scene.