Missing ... Madeleine McCann has been missing since 2007. Picture: Supplied. Source: News Corp Australia

Four women and seven men will be quizzed about the disappearance of the British girl from a hotel room in the Algarve resort of Praia da Luz seven years ago.

Among those being questioned will be British expat Robert Murat, who was first questioned when the toddler was reported missing by her parents, reports said.

Suspect ... Robert Muratis under formal investigation in the disappearance of Madeleine McCann. Picture: Supplied. Source: AFP

Employees of the holiday complex where Madeleine disappeared on May 3, 2007 are also among those being questioned.

Scotland Yard inspectors are believed to have flown to Portugal to meet with Portuguese detectives handling the case.

Madeleine, then aged nearly four, disappeared from her bedroom as her parents were dining with friends at a nearby tapas bar.

Were suspects ... Gerry and Kate McCann, the parents of missing British girl Madeleine, in 2010, have had to deny their involvement in their daughter’s disappearance. Picture: Supplied. Source: AP

Portuguese police closed their investigation in 2008 after 14 months, which at one point implicated her parents in her abduction before their names were cleared.

After two years studying the case, Britain officially opened its own investigative review of the evidence in July last year and the Portuguese authorities reopened their case shortly afterwards.