Economic development will be on the agenda for South Australia's party leaders when they come face to face at another debate in the lead-up to the March 17 state election.

Premier Jay Weatherill, Opposition Leader Steven Marshall and SA-BEST leader Nick Xenophon will square off at an event hosted by the Committee for the Economic Development of Australia (CEDA) on Wednesday.

It will be the second debate in as many days for the leaders, who traded barbs on environmental issues on Tuesday.

The trio clashed over renewable energy targets and, as he did at last week's Property Council debate, Mr Xenophon also came under attack from Mr Marshall for a lack of policies.

"On nearly every single topic he's got a buffer or a stopper or something to talk about, which really gets away from the fact that SA-BEST has no policies whatsoever to enhance the environment," he said.

Mr Marshall is expected to make a similar assessment of the former senator's economic credentials while the Mr Xenophon is likely to talk up his call for voters to back his group as the "sensible centre" of politics.

Mr Weatherill will continue to push Labor's claim to be the only party that stands up for the people of South Australia.

On Tuesday Mr Xenophon released his party's first campaign commercial before the March 17 poll, featuring himself rapping about the state's problems.

Crime, health, government overspending and the brain drain are among the issues highlighted in the video, which portrays SA-BEST as a "a true blue caring party" ready to solve the state's issues.

SA-BEST will run candidates in more 35 seats in a bid to secure the balance of power in the next parliament.