Speaking to journalists in North India, the Tibetan spiritual leader expressed his grief over the ongoing violence inside Buddhist-majority Myanmar on Friday, saying the Buddha would have "definitely helped" the Rohingya.
"They should remember, Buddha, in such circumstances, Buddha (would have) definitely helped those poor Muslims. So, still I feel that (it's) so very sad ... so sad," he told reporters.
The Rohingya, considered to be among the world's most persecuted people, are denied the right to citizenship in Myanmar despite having lived there for generations, making them effectively stateless.
They've been the subject of multiple clearance operations by Myanmar's military, the latest of which intensified in late August following an attack on border posts by Rohingya militants.
Nobel laureates condemn Suu Kyi
The Dalai Lama is the latest international human rights leader to call for an end to the violence.
"I am ... breaking my vow of silence on public affairs out of profound sadness about the plight of the Muslim minority in your country, the Rohingya," he wrote in an open letter, posted on his official Twitter feed.
Tutu described the campaign against the Rohingya as a "slow genocide."
"The images we are seeing of the suffering of the Rohingya fill us with pain and dread," he said. "If the political price of your ascension to the highest office in Myanmar is your silence, the price is surely too steep."
"Over the last several years, I have repeatedly condemned this tragic and shameful treatment. I am still waiting for my fellow Nobel Laureate Aung San Suu Kyi to do the same," she wrote on September 4.
CNN's Sugam Pokharel contributed to this report.