South Sydney could be without brothers Tom and George Burgess for their round- two clash against Manly after both were left out of Rabbitohs' top-17 on Tuesday.

George got a recall to an extended bench, however Tom was left out of the 21-man squad as coach Michael Maguire searches for a winning combination after their first-up loss.

Alex Johnston has been named to start in the No.1 jumper vacated by injured star Greg Inglis, with rookie Braidon Burns set to make his NRL debut on the wing.

In good news for Rabbitohs fans, halfback Adam Reynolds is a chance of making an early return from appendicitis after being included on the extras list.

The State of Origin halfback will need a medical clearance later this week to face Manly. 

The Sea Eagles have been forced into numerous changes after suspensions to Martin Taupau and Addin Fonua-Blake, and a fractured eye socket for Lloyd Perrett.

New buys Jarrad Kennedy and Shaun Lane come into the 17, along with utility Cameron Cullen.

The other big inclusion among NRL squads is high-profile Brisbane signing Benji Marshall, who was named in the No.18 jumper for their local derby against North Queensland.

Fellow utility Kodi Nikorima has also been selected in an otherwise unchanged line-up to take on a Cowboys side buoyed by the return of winger Antonio Winterstein.

In Melbourne, Tim Glasby has gotten the nod to deputise for Jesse Bromwich (thumb), with rookie Joe Stimson pencilled in for his first game in the big time.

Brendan Elliot has been picked to replace injured youngster Dylan Phythian (ACL) at fullback in Newcastle's change, while Penrith named Dylan Edwards for Peta Hiku (eye socket).

As expected, Canberra received a boost ahead of their clash against Cronulla with fullback Jack Wighton (illness) and Junior Paulo (suspension) coming back.

However, Clay Priest (suspension) and Joseph Tapine (finger) are out, with Scott Sorensen in.

"Jack's six-foot-two and really solid in defence and another big body. He's going to be really handy for us," Raiders star Blake Austin said on Tuesday.

"Throw big Junior Paulo in there, hopefully he'll make an immediate mark as well.

"You never like injuries but we've just got to deal with it. I thought we dealt with it pretty well on the weekend, and we've got to be better this week."

The Sydney Roosters, Canterbury, the Warriors, Gold Coast, St George-Illawarra, Parramatta and the Wests Tigers are unchanged.

AAP with Fairfax Media