The launch would almost triple the current record of 37 satellites Russia sent into orbit in 2014.
"It's going to be a big deal. It shows the sophistication of India's space program," says Rajeswari Pillai Rajagopalan, head of the Nuclear and Space Policy Initiative at the Observer Research Foundation.
The increasing competition for space-related power and prestige in Asia has echoes of the Cold War space race of the mid-20th century.
But they're not the only motivations. The pursuit of science and technological advancement plus the economic and commercial benefits they bring also factor highly.
"I've long said that the real race is in Asia," says Joan Johnson-Freese, a professor and space specialist at the US Naval War College.
"Recognition of the multifaceted benefits from space exploration and space technology dates back to the Apollo program. Asian countries have been following that model and seeking those benefits ever since."
India: Frugal innovation
India's Mangalyaan probe -- Asia's first successful Mars orbiter -- forced the world to take note of India's space program, which was set up in 1962.
The probe was famously sent to the Red Planet in 2014 for $74 million -- less than the $100 million than Hollywood spent making space thriller "Gravity." The Mangalyaan now has pride of place on India's new 2,000 rupee note.
"It was a 'beat the Chinese' mission which they hoped would translate into regional and global prestige cum leadership. Anything that gets you into the records book -- like breaking the Russian satellite launch record -- falls into a similar category," says Johnson-Freese.
The Mars mission was not just a "sound and light show," says Rajagopalan. It established India's credibility as a space power and has translated into tangible economic benefits when it comes to the big business of satellite launches.
To date India has launched 79 satellites from 21 countries, including satellites from big companies like Google and Airbus, earning India at least $157 million, according to government figures.
In 2016, it launched 20 satellites in one go but Wednesday's launch is a far bigger challenge.
The rocket's payload includes three Indian satellites and a 101 foreign satellites from six countries -- US, Kazakhstan, Israel, Netherlands, Switzerland and UAE, according to the Indian Space Research Organization (ISRO).
"The secondary satellites are often not very big so we are able to carry many of them," says Ramabhadran Aravamudan, former director of the ISRO Satellite Center in Bangalore and the author of a new book on India's space program.
"The main technology involved is to launch them in a sequence so they don't interfere with each other and go into separate orbits."
Low costs bring in customers
Uday Bhaskar, director at the Society for Policy Studies, a Delhi-based think tank, says India can put a satellite into space at a price that is "60% to 70% lower" than other countries.
Aravamudan says this is largely down to cheaper labor costs and a state-led model that doesn't involve "industries with their own profit margins."
For example, highly-skilled aerospace engineers in India might receive a salary of $1,000 per month, a fraction of what they could earn in Europe or the US.
However, India will remain a "modest player" globally unless it can start sending heavier satellites into orbit.
"We still don't have a decent cryogenic engine for heavy launches," says Bhaskar.
What's next
In the first half of 2018, India plans to launch its second lunar mission -- in 2008, it became the fourth country to plant its flag on the moon after the US, Russia and China.
The Chandrayaan-2 will orbit, land and send a wheeled rover on the moon to collect lunar rock or soil. India also plans a mission to study the sun, plus proposed mission to Venus and a follow up to its first Mars mission
For now, manned missions aren't being pursued but are a possibility.
China, India's great regional rival for superpower status and the most rapidly accelerating space power, is also gearing up for a busy few years.
It will test its Tianzhou-1 cargo and resupply spacecraft in April -- a key technology needed for country's space station that's expected to be up and running by 2022.
Later in the year, will send a probe to the moon that will collect and return with soil sample.
By the end of the decade, China says it will have also become the first country to land on the far side of the moon and also wants to land a rover on Mars.
Japan plays catch-up
It was supposed to be proof of concept for Japan's micro-satellite and mini-rocket technology, which JAXA hopes to commercialize as private companies seek cheaper options that are easier to put into orbit.
"Japan cannot be seen to be left behind given their longtime reputation of the Asian technology leader, even if largely through consumer goods," says Johnson-Freese.
"Consequently they too must if not exceed then 'keep up' with other Asian space nations."