A fuel tanker has overturned in regional Victoria, with power cut off to nearby residents.

The tanker overturned at the corner of the Calder Highway and Sullivan Street in Inglewood about 7.50pm on Wednesday.

An emergency warning of a fuel spill has been issued, with residents in the Heales Street area asked to leave immediately for the Inglewood Senior Citizen's centre on Grant Street.

Power lines are down, with electricity to Inglewood cut off and residents advised not to use any power appliances.

Eighteen CFA trucks are on scene.

More to come.